Endocrine Abstracts

Background and aim: Patients with GH deficiency (GHD) have increased risk of cerebrovascular events. The aim of this study was to evaluate the rate and factors associated with the occurrence of stroke, a major cause of death and disability, in adults with GHD.Patients and methods: Data from 15,188 GHD patients treated with GH replacement therapy (GHRT) enrolled in KIMS were analyzed. Stroke incidence rates were compared to rates from the Oxford Vascular ...

Objective: To identify MetS and non-MetS in subjects with adult-onset GHD before start of GH replacement and to compare prevalence of cardiovascular risk factors.Subjects and methods: MetS was defined (IDF criteria) by the obligatory presence of increased waist circumference (WC) and presence of at least two of following components: hypertension, decreased HDL-cholesterol, increased triglycerides, diabetes mellitus. The complementary group was defined as...

Growth hormone (GH) replacement in adults with severe GH deficiency (GHD) has well established beneficial effects on the cardiovascular risk profile. Whether this is associated with reduced mortality is still unclear. The present study addresses this question by analysing mortality data in KIMS (Pfizer international metabolic database) and is based on 9610 patients (47% females), accumulating 37882 patient-years of follow-up. There were 257 recorded deaths against 255.1 expect...

Background: The aim of the Swedish Pituitary Register – the Swedish Pituitary Study Group’s quality register – is to guarantee that all patients with pituitary tumours get equivalent diagnostic evaluation and treatment, as well as to evaluate given therapy. In this study, patients diagnosed with acromegaly from 1991 are described.Methods: Data from 557 patients (275 men/282 women), median age 51 years (range 4–87), with acromegaly wer...

Background: Untreated GH-deficiency (GHD) in adults has been suggested to be associated with an increased prevalence of type 2 diabetes mellitus (DM). Proposed causative factors are the tendency to overweight and the insulin resistance due to central adiposity.Patients and methods: The KIMS (Pfizer International Metabolic Database) was used to evaluate the prevalence of DM in both childhood-onset (CO; n=1977; 56% males) and in adult-onset (AO; ...